Procedural characteristics varied for the 2 access routes.Importantly, the crossover rate from radial to femoral was 10.1% andfrom femoral to radial was 1.2%; all results were analyzed according tointention to treat. Optimal antithrombotic therapy was given to 87.4%of the radial group compared with 69.6% of the femoral group (P< 0.001). Procedural success (defined as improvement in TIMI flowafter PCI) was observed more frequently with radial access (94.5% vs.88.4%; P = 0.04).< ="Content-" content="text/; charset=utf-8">< name="ProgId" content="Word.">< name="Generator" content="Microsoft Word 11">< name="Originator" content="Microsoft Word 11"><><strong><ahref="http://www.brandsjeansonline.com/">true religion jeanssale</a></strong>

The study’s co-primary endpoints were major bleeding and time torevascularization. The latter was similar for the 2 approaches,amounting to 21 ± 9 minutes with radial access and 23 ± 10 minutes withfemoral access.

Major bleeding, however, was dramatically lower with the radial approach (2.9% vs. 14.3%; P< 0.0001). In the femoral group, no difference was seen betweenpatients who did or did not receive a closure device. Multivariatelogistic regression analysis found that the strongest predictor ofmajor bleeding was femoral access (OR 5.13; 95% CI 2.05-12.83).

At 1-year follow-up, radial access reduced both death and TVR, whichtranslated into a lower MACE rate despite an equal incidence of MIbetween the treatment arms (table 1).< ="Content-" content="text/; charset=utf-8">< name="ProgId" content="Word.">< name="Generator" content="Microsoft Word 11">< name="Originator" content="Microsoft Word 11"><>

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Olivier F. Bertrand, MD, PhD, of Hôpital Laval (Quebec City,Canada), told TCTMD in a telephone interview that an interesting aspectof the paper is that it captures the experience of a center juststarting to move toward the radial approach.< ="Content-" content="text/; charset=utf-8">< name="ProgId" content="Word.">< name="Generator" content="Microsoft Word 11">< name="Originator" content="Microsoft Word 11"><>

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Given the center’s experience level, Dr. Bertrand said, it isnoteworthy that radial access carried no time penalty and that it sodramatically reduced major bleeding.< ="Content-" content="text/; charset=utf-8">< name="ProgId" content="Word.">< name="Generator" content="Microsoft Word 11">< name="Originator" content="Microsoft Word 11"><>true religion jeans

“One thing not said in the manuscript is that usually when you usethe radial approach, you completely remove access site bleeding fromthe equation,” he commented. But because the HORIZONS-AMI definition ofmajor bleeding is a composite, it is impossible to know exactly whattypes of bleeding were reduced, “if it was confined to just access sitebleeding or if it was also non-access site bleeding,< ="Content-" content="text/; charset=utf-8">< name="ProgId" content="Word.">< name="Generator" content="Microsoft Word 11">< name="Originator" content="Microsoft Word 11"><>

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Olivier F. Bertrand, MD, PhD, of Hôpital Laval (Quebec City,Canada), told TCTMD in a telephone interview that an interesting aspectof the paper is that it captures the experience of a center juststarting to move toward the radial approach.< ="Content-" content="text/; charset=utf-8">< name="ProgId" content="Word.">< name="Generator" content="Microsoft Word 11">< name="Originator" content="Microsoft Word 11"><>

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“One thing not said in the manuscript is that usually when you usethe radial approach, you completely remove access site bleeding fromthe equation,” he commented. But because the HORIZONS-AMI definition ofmajor bleeding is a composite, it is impossible to know exactly whattypes of bleeding were reduced,< ="Content-" content="text/; charset=utf-8">< name="ProgId" content="Word.">< name="Generator" content="Microsoft Word 11">< name="Originator" content="Microsoft Word 11"><>

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